Knee-OA studies used chondroitin sulfate 800–1,200 mg/day for 3–24 months
Reviewed · Published
Chondroitin
A sulfated polysaccharide with inconsistent joint-symptom effects across products and trials.
Established functions
- A sulfated polysaccharide with inconsistent joint-symptom effects across products and trials.
Dietary sources
- cartilage
- fish cartilage
Claims and evidence
Claims that Chondroitin alone prevents or treats disease, or invariably improves health without deficiency, are unsupported.
Japanese reference amounts
- Japanese adults (age and sex as specified): No Japanese DRI established
Amounts studied
- Knee-OA studies used chondroitin sulfate 800–1,200 mg/day for 3–24 months
Tolerable upper limits
- No UL; long-term ceiling unknown
Forms and bioavailability
Supplement forms: bovine chondroitin sulfate, marine chondroitin sulfate
- Molecular weight, purity, and animal source vary substantially.
Safety and interactions
Adverse effects
- gastrointestinal symptoms
- edema
- bleeding tendency
Medicine and nutrient interactions
- warfarin, antiplatelets
Contraindications and cautions
- Consult with anticoagulation or allergy to the animal source.
Practical selection
- Compare Chondroitin amount per serving, form, allergens, and batch testing; prefer a single-ingredient product suited to the intended use.
Sources and review
- Osteoarthritis management guidelineAmerican College of Rheumatology
Daiki Minaki (editorial and evidence review) ·