Small dry-skin studies used oral 120–240 mg/day for 6–12 weeks
Reviewed · Published
Hyaluronic acid
A water-binding glycosaminoglycan; oral products are distinct from injections.
Established functions
- A water-binding glycosaminoglycan; oral products are distinct from injections.
Dietary sources
- rooster comb
- animal tissues
Claims and evidence
Claims that Hyaluronic acid alone prevents or treats disease, or invariably improves health without deficiency, are unsupported.
Japanese reference amounts
- Japanese adults (age and sex as specified): No Japanese DRI established
Amounts studied
- Small dry-skin studies used oral 120–240 mg/day for 6–12 weeks
Tolerable upper limits
- No UL; long-term data are limited
Forms and bioavailability
Supplement forms: fermentation-derived sodium hyaluronate, rooster-comb-derived
- Molecular weight may affect uptake and action, limiting extrapolation across products.
Safety and interactions
Adverse effects
- gastrointestinal symptoms
- source allergy
Medicine and nutrient interactions
- few established medicine interactions
Contraindications and cautions
- Consult during pregnancy, lactation, or cancer treatment because data are sparse.
Practical selection
- Compare Hyaluronic acid amount per serving, form, allergens, and batch testing; prefer a single-ingredient product suited to the intended use.
Sources and review
- NCCIH Herbs at a Glance and supplement safety resourcesNational Center for Complementary and Integrative Health
Daiki Minaki (editorial and evidence review) ·