Small blood-pressure studies used 2,000 FU/day for 8 weeks; this is not a thrombosis-prevention dose
Reviewed · Published
Nattokinase
An enzyme produced during natto fermentation; oral prevention of clinical thrombosis is unproven.
Established functions
- An enzyme produced during natto fermentation; oral prevention of clinical thrombosis is unproven.
Dietary sources
- natto
Claims and evidence
Claims that Nattokinase alone prevents or treats disease, or invariably improves health without deficiency, are unsupported.
Japanese reference amounts
- Japanese adults (age and sex as specified): No Japanese DRI established
Amounts studied
- Small blood-pressure studies used 2,000 FU/day for 8 weeks; this is not a thrombosis-prevention dose
Tolerable upper limits
- No UL; a safe ceiling is unknown because of bleeding risk
Forms and bioavailability
Supplement forms: fermented-culture extract, vitamin-K-removed extract
- Check FU activity and vitamin K content; extracts are not equivalent to natto food.
Safety and interactions
Adverse effects
- bleeding
- bruising
- allergy
Medicine and nutrient interactions
- anticoagulants, antiplatelets, thrombolytics
Contraindications and cautions
- Avoid with bleeding disorders, before surgery, in pregnancy, or during anticoagulation.
Practical selection
- Compare Nattokinase amount per serving, form, allergens, and batch testing; prefer a single-ingredient product suited to the intended use.
Sources and review
- NCCIH Herbs at a Glance and supplement safety resourcesNational Center for Complementary and Integrative Health
Daiki Minaki (editorial and evidence review) ·
Frequently asked questions
How is Nattokinase different from its broader supplement category?
An enzyme produced during natto fermentation; oral prevention of clinical thrombosis is unproven. Compare its named form and amount rather than assuming every category product supplies it.
View detailsWhat safety detail matters specifically for Nattokinase?
anticoagulants, antiplatelets, thrombolytics Avoid with bleeding disorders, before surgery, in pregnancy, or during anticoagulation.
View details