Small lipid or fatigue-marker studies used 10–50 mg/day for 4–12 weeks in adults
Reviewed · Published
Sesamin
A sesame lignan with limited small human outcome studies.
Established functions
- A sesame lignan with limited small human outcome studies.
Dietary sources
- sesame seeds
- sesame oil
Claims and evidence
Claims that Sesamin alone prevents or treats disease, or invariably improves health without deficiency, are unsupported.
Japanese reference amounts
- Japanese adults (age and sex as specified): No Japanese DRI established
Amounts studied
- Small lipid or fatigue-marker studies used 10–50 mg/day for 4–12 weeks in adults
Tolerable upper limits
- No UL; long-term ceiling for concentrates is unknown
Forms and bioavailability
Supplement forms: sesame lignan extract, sesamin-enriched oil
- Fat-soluble and taken with food; extracts do not replace the whole nutritional profile of sesame.
Safety and interactions
Adverse effects
- gastrointestinal symptoms
- sesame allergy
Medicine and nutrient interactions
- clinical significance of interactions with liver-metabolized medicines is unknown
Contraindications and cautions
- Contraindicated in sesame allergy.
Practical selection
- Compare Sesamin amount per serving, form, allergens, and batch testing; prefer a single-ingredient product suited to the intended use.
Sources and review
- NCCIH Herbs at a Glance and supplement safety resourcesNational Center for Complementary and Integrative Health
Daiki Minaki (editorial and evidence review) ·