Knee-OA studies used crystalline glucosamine sulfate 1,500 mg/day for 6 months to 3 years; do not extrapolate to hydrochloride
Reviewed · Published
Glucosamine
An amino sugar with formulation-dependent osteoarthritis evidence.
Established functions
- An amino sugar with formulation-dependent osteoarthritis evidence.
Dietary sources
- shellfish shells
- cartilage
Claims and evidence
Claims that Glucosamine alone prevents or treats disease, or invariably improves health without deficiency, are unsupported.
Japanese reference amounts
- Japanese adults (age and sex as specified): No Japanese DRI established
Amounts studied
- Knee-OA studies used crystalline glucosamine sulfate 1,500 mg/day for 6 months to 3 years; do not extrapolate to hydrochloride
Tolerable upper limits
- No UL; long-term safe ceiling unknown
Forms and bioavailability
Supplement forms: crystalline glucosamine sulfate, glucosamine hydrochloride
- Check salt form and actual glucosamine content.
Safety and interactions
Adverse effects
- gastrointestinal symptoms
- drowsiness
- glucose changes
Medicine and nutrient interactions
- warfarin, diabetes medicines
Contraindications and cautions
- Check source with shellfish allergy; avoid during warfarin therapy.
Practical selection
- Compare Glucosamine amount per serving, form, allergens, and batch testing; prefer a single-ingredient product suited to the intended use.
Sources and review
- Osteoarthritis management guidelineAmerican College of Rheumatology
Daiki Minaki (editorial and evidence review) ·